Chemopreventive n-3 fatty acids activate RXR in colonocytes
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چکیده
منابع مشابه
n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes.
Ras proteins are critical regulators of cell function, including growth, differentiation, and apoptosis, with membrane localization of the protein being a prerequisite for malignant transformation. We have recently demonstrated that feeding fish oil, compared with corn oil, decreases colonic Ras membrane localization and reduces tumor formation in rats injected with a colon carcinogen. Because ...
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Copyright © 2011 Massachusetts Medical Society. Cardiovascular disease is the leading cause of death worldwide, and preventive approaches, particularly achievable dietary changes, have major public health implications. An increased dietary intake of n–3 (polyunsaturated) fatty acids is one such dietary approach. This review discusses advances since the topic was last reviewed in the Journal1 an...
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Copyright © 2011 Massachusetts Medical Society. Cardiovascular disease is the leading cause of death worldwide, and preventive approaches, particularly achievable dietary changes, have major public health implications. An increased dietary intake of n–3 (polyunsaturated) fatty acids is one such dietary approach. This review discusses advances since the topic was last reviewed in the Journal1 an...
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Increased concentrations of free arachidonic acid (AA) and its proinflammatory metabolites have been observed in psoriatic lesions. Replacement of arachidonic acid by alternative precursor polyunsaturated fatty acids (PUFA), especially eicosapentaenoic acid (EPA), which can be metabolized via the same enzymatic pathways as AA, might be a therapeutic option in psoriasis. However the results of s...
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To the Editor: In the editorial “N-3 fatty acids: priority for post–myocardial infarction clinical trials,” Dr Scott Grundy1 (somewhat cautiously) endorsed the need for a trial to test the hypothesis that -3 fatty acid (FA) supplements will reduce risk for coronary death in patients randomized in the immediate post–myocardial infarction period. We support this recommendation, but we differ with...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2003
ISSN: 1460-2180
DOI: 10.1093/carcin/bgg110